Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide.

The translocation from chromosome 8 to chromosome 21, t(8;21), associated with acute myeloid leukemia results in production of an AML1/MTG8(ETO) fusion transcript. The product of the AML1 gene contains an evolutionarily conserved 128-amino acid region referred to as the "Runt domain," which is neces...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Sakakura, C, Yamaguchi-Iwai, Y, Satake, M, Bae, S C, Takahashi, A, Ogawa, E, Hagiwara, A, Takahashi, T, Murakami, A, Makino, K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45304/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7972130/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.24.11723
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