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The Prion Protein N1 and N2 Cleavage Fragments Bind to Phosphatidylserine and Phosphatidic Acid; Relevance to Stress-Protection Responses

Internal cleavage of the cellular prion protein generates two well characterised N-terminal fragments, N1 and N2. These fragments have been shown to bind to anionic phospholipids at low pH. We sought to investigate binding with other lipid moieties and queried how such interactions could be relevant...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Haigh, Cathryn L., Tumpach, Carolin, Drew, Simon C., Collins, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529310/
https://ncbi.nlm.nih.gov/pubmed/26252007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134680
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