The prion protein regulates beta-amyloid-mediated self-renewal of neural stem cells in vitro

The beta-amyloid (Aβ) peptide and the Aβ-oligomer receptor, prion protein (PrP), both influence neurogenesis. Using in vitro murine neural stem cells (NSCs), we investigated whether Aβ and PrP interact to modify neurogenesis. Aβ imparted PrP-dependent changes on NSC self-renewal, with PrP-ablated an...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Collins, Steven J, Tumpach, Carolin, Li, Qiao-Xin, Lewis, Victoria, Ryan, Timothy M, Roberts, Blaine, Drew, Simon C, Lawson, Victoria A, Haigh, Cathryn L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435829/
https://ncbi.nlm.nih.gov/pubmed/25884827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-015-0067-4
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