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Towards more drug-like proteomimetics: Two-faced, synthetic α-helix mimetics based on a purine scaffold

Mimicry of two faces of an α-helix might yield more potent and more selective inhibitors of dysregulated, helix-mediated protein–protein interactions (PPI). Herein, we demonstrate that a 2,6,9-tri-substituted purine is capable of disrupting the Mcl-1–Bak-BH3 PPI through effective mimicry of key resi...

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Bibliografiske detaljer
Udgivet i:Org Biomol Chem
Main Authors: Lanning, M. E., Wilder, P. T., Bailey, H., Drennen, B., Cavalier, M., Chen, L., Yap, J. L., Raje, Mithun, Fletcher, S.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528301/
https://ncbi.nlm.nih.gov/pubmed/26204921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob00478k
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