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Towards more drug-like proteomimetics: Two-faced, synthetic α-helix mimetics based on a purine scaffold
Mimicry of two faces of an α-helix might yield more potent and more selective inhibitors of dysregulated, helix-mediated protein–protein interactions (PPI). Herein, we demonstrate that a 2,6,9-tri-substituted purine is capable of disrupting the Mcl-1–Bak-BH3 PPI through effective mimicry of key resi...
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| Veröffentlicht in: | Org Biomol Chem |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4528301/ https://ncbi.nlm.nih.gov/pubmed/26204921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob00478k |
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