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Novel Allosteric Modulators of G Protein-coupled Receptors

G protein-coupled receptors (GPCRs) are allosteric proteins, because their signal transduction relies on interactions between topographically distinct, yet conformationally linked, domains. Much of the focus on GPCR allostery in the new millennium, however, has been on modes of targeting GPCR allost...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Gentry, Patrick R., Sexton, Patrick M., Christopoulos, Arthur
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528113/
https://ncbi.nlm.nih.gov/pubmed/26100627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R115.662759
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