AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

Long-term delivery of potent broadly-neutralizing antibodies is a promising approach for the prevention of HIV-1 infection. We used AAV vector intramuscularly to deliver anti-SIV monoclonal antibodies (mAbs) in IgG1 form to rhesus monkeys. Persisting levels of delivered mAb as high as 270 μg/ml were...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:PLoS Pathog
Autors principals: Fuchs, Sebastian P., Martinez-Navio, José M., Piatak, Michael, Lifson, Jeffrey D., Gao, Guangping, Desrosiers, Ronald C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527674/
https://ncbi.nlm.nih.gov/pubmed/26248318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005090
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars