AAV-delivered eCD4-Ig protects rhesus macaques from high-dose SIVmac239 challenges

A number of simian and simian human immunodeficiency viruses (SIV and SHIV) have been used to assess the efficacy of HIV-1 vaccine strategies. Among these, SIVmac239 is considered among the most stringent because, unlike SHIV models, its full genome has co-evolved in its macaque host and its tier 3...

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Udgivet i:Sci Transl Med
Main Authors: Gardner, Matthew R., Fellinger, Christoph H., Kattenhorn, Lisa M., Davis-Gardner, Meredith E., Weber, Jesse A., Alfant, Barnett, Zhou, Amber S., Prasad, Neha R., Kondur, Hema R., Newton, Wendy A., Weisgrau, Kim L., Rakasz, Eva G., Lifson, Jeffrey D., Gao, Guangping, Schultz-Darken, Nancy, Farzan, Michael
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716512/
https://ncbi.nlm.nih.gov/pubmed/31341061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau5409
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