Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies

Adeno-associated virus (AAV) delivery of potent and broadly neutralizing antibodies (bNAbs is a promising approach for the prevention of HIV-1 infection. The immunoglobulin G (IgG)1 subtype is usually selected for this application, because it efficiently mediates antibody effector functions and has...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Gardner, Matthew R., Fetzer, Ina, Kattenhorn, Lisa M., Davis-Gardner, Meredith E., Zhou, Amber S., Alfant, Barnett, Weber, Jesse A., Kondur, Hema R., Martinez-Navio, Jose M., Fuchs, Sebastian P., Desrosiers, Ronald C., Gao, Guangping, Lifson, Jeffrey D., Farzan, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403482/
https://ncbi.nlm.nih.gov/pubmed/30704961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.01.004
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