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Interdependence of the Rad50 hook and globular domain functions

Rad50 contains a conserved Zn(2+) coordination domain (the Rad50 hook) that functions as a homodimerization interface. Hook ablation phenocopies Rad50 deficiency in all respects. Here we focused on rad50 mutations flanking the Zn(2+)-coordinating hook cysteines. These mutants impaired hook-mediated...

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Bibliografiske detaljer
Udgivet i:Mol Cell
Main Authors: Hohl, Marcel, Kochańczyk, Tomasz, Tous, Cristina, Aguilera, Andrés, Krężel, Artur, Petrini, John H J
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527088/
https://ncbi.nlm.nih.gov/pubmed/25601756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.12.018
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