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Interdependence of the Rad50 hook and globular domain functions
Rad50 contains a conserved Zn(2+) coordination domain (the Rad50 hook) that functions as a homodimerization interface. Hook ablation phenocopies Rad50 deficiency in all respects. Here we focused on rad50 mutations flanking the Zn(2+)-coordinating hook cysteines. These mutants impaired hook-mediated...
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| Publicado en: | Mol Cell |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4527088/ https://ncbi.nlm.nih.gov/pubmed/25601756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.12.018 |
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