The Rad50 hook domain regulates DNA damage signaling and tumorigenesis

The Mre11 complex (Mre11, Rad50, and Nbs1) is a central component of the DNA damage response (DDR), governing both double-strand break repair and DDR signaling. Rad50 contains a highly conserved Zn(2+)-dependent homodimerization interface, the Rad50 hook domain. Mutations that inactivate the hook do...

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Detalhes bibliográficos
Main Authors: Roset, Ramon, Inagaki, Akiko, Hohl, Marcel, Brenet, Fabienne, Lafrance-Vanasse, Julien, Lange, Julian, Scandura, Joseph M., Tainer, John A., Keeney, Scott, Petrini, John H.J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950343/
https://ncbi.nlm.nih.gov/pubmed/24532689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.236745.113
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