Cohesin association to replication sites depends on Rad50 and promotes fork restart

The cohesin complex holds together newly-replicated chromatids and is involved in diverse pathways that preserve genome integrity. We show that in budding yeast, cohesin is transiently recruited to active replication origins and it spreads along DNA as forks progress. When DNA synthesis is impeded,...

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Main Authors: Tittel-Elmer, Mireille, Lengronne, Armelle, Davidson, Marta B, Bacal, Julien, François, Philippe, Hohl, Marcel, Petrini, John H J, Pasero, Philippe, Cobb, Jennifer A
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904740/
https://ncbi.nlm.nih.gov/pubmed/22885006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.07.004
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