The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress

The Mre11–Rad50–Xrs2 (MRX) complex has an important function in the maintenance of genomic integrity by contributing to the detection and repair of chromosome breaks. Here we show that the complex is recruited to sites of paused forks where it stabilizes the association of essential replisome compon...

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Hauptverfasser: Tittel-Elmer, Mireille, Alabert, Constance, Pasero, Philippe, Cobb, Jennifer A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683708/
https://ncbi.nlm.nih.gov/pubmed/19279665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.60
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