Restoring allosterism with compensatory mutations in hemoglobin.

Abnormal human hemoglobins (HBs) with amino acid substitutions in the alpha 1 beta 2 interface have very high oxygen affinity and greatly reduced cooperativity in O2 binding compared to normal human Hb. In such abnormal Hbs with mutations at position beta 99, the intersubunit hydrogen bonds between...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kim, H W, Shen, T J, Sun, D P, Ho, N T, Madrid, M, Tam, M F, Zou, M, Cottam, P F, Ho, C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45268/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7972099/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.24.11547
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