Restoring allosterism with compensatory mutations in hemoglobin.

Abnormal human hemoglobins (HBs) with amino acid substitutions in the alpha 1 beta 2 interface have very high oxygen affinity and greatly reduced cooperativity in O2 binding compared to normal human Hb. In such abnormal Hbs with mutations at position beta 99, the intersubunit hydrogen bonds between...

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Bibliografische Detailangaben

Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Kim, H W, Shen, T J, Sun, D P, Ho, N T, Madrid, M, Tam, M F, Zou, M, Cottam, P F, Ho, C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45268/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7972099/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.24.11547
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