Restoring allosterism with compensatory mutations in hemoglobin.

Abnormal human hemoglobins (HBs) with amino acid substitutions in the alpha 1 beta 2 interface have very high oxygen affinity and greatly reduced cooperativity in O2 binding compared to normal human Hb. In such abnormal Hbs with mutations at position beta 99, the intersubunit hydrogen bonds between...

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Detaylı Bibliyografya
Asıl Yazarlar: Kim, H W, Shen, T J, Sun, D P, Ho, N T, Madrid, M, Tam, M F, Zou, M, Cottam, P F, Ho, C
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1994
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC45268/
https://ncbi.nlm.nih.gov/pubmed/7972099
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