Compensatory Mutations Restore Fitness during the Evolution of Dihydrofolate Reductase

Whether a trade-off exists between robustness and evolvability is an important issue for protein evolution. Although traditional viewpoints have assumed that existing functions must be compromised by the evolution of novel activities, recent research has suggested that existing phenotypes can be rob...

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Detaylı Bibliyografya
Asıl Yazarlar: Brown, Kyle M., Costanzo, Marna S., Xu, Wenxin, Roy, Scott, Lozovsky, Elena R., Hartl, Daniel L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2010
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981517/
https://ncbi.nlm.nih.gov/pubmed/20576759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msq160
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