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Preservation of Protein Dynamics in Dihydrofolate Reductase Evolution
The hydride transfer reaction catalyzed by dihydrofolate reductase (DHFR) is a model for examining how protein dynamics contribute to enzymatic function. The relationship between functional motions and enzyme evolution has attracted significant attention. Recent studies on N23PP Escherichia coli DHF...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3861645/ https://ncbi.nlm.nih.gov/pubmed/24158440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.507632 |
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