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Protein Motions and the Activation of the C-H Bond Catalyzed by Dihydrofolate Reductase

The role of protein motions in enzymatic C-H→C transfer is an area of great contemporary debate. An effective tool in probing such a role is the temperature dependence of the intrinsic kinetic isotope effects for the enzyme-catalyzed reaction. The outcome of those experiments is interpreted within t...

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Bibliografski detalji
Glavni autori: Francis, Kevin, Kohen, Amnon
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149937/
https://ncbi.nlm.nih.gov/pubmed/24742825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2014.03.009
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