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Protein Motions and the Activation of the C-H Bond Catalyzed by Dihydrofolate Reductase
The role of protein motions in enzymatic C-H→C transfer is an area of great contemporary debate. An effective tool in probing such a role is the temperature dependence of the intrinsic kinetic isotope effects for the enzyme-catalyzed reaction. The outcome of those experiments is interpreted within t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4149937/ https://ncbi.nlm.nih.gov/pubmed/24742825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2014.03.009 |
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