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Protein Motions and the Activation of the C-H Bond Catalyzed by Dihydrofolate Reductase
The role of protein motions in enzymatic C-H→C transfer is an area of great contemporary debate. An effective tool in probing such a role is the temperature dependence of the intrinsic kinetic isotope effects for the enzyme-catalyzed reaction. The outcome of those experiments is interpreted within t...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4149937/ https://ncbi.nlm.nih.gov/pubmed/24742825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2014.03.009 |
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