Disturbed Cholesterol Traffic but Normal Proteolytic Function in LAMP-1/LAMP-2 Double-deficient Fibroblasts

Mice double deficient in LAMP-1 and -2 were generated. The embryos died between embryonic days 14.5 and 16.5. An accumulation of autophagic vacuoles was detected in many tissues including endothelial cells and Schwann cells. Fibroblast cell lines derived from the double-deficient embryos accumulated...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Eskelinen, Eeva-Liisa, Schmidt, Christine Katrin, Neu, Silja, Willenborg, Marion, Fuertes, Graciela, Salvador, Natalia, Tanaka, Yoshitaka, Lüllmann-Rauch, Renate, Hartmann, Dieter, Heeren, Jörg, von Figura, Kurt, Knecht, Erwin, Saftig, Paul
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Cell Biology 2004
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC452571/
https://ncbi.nlm.nih.gov/pubmed/15121881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-02-0103
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