Disturbed Cholesterol Traffic but Normal Proteolytic Function in LAMP-1/LAMP-2 Double-deficient Fibroblasts

Mice double deficient in LAMP-1 and -2 were generated. The embryos died between embryonic days 14.5 and 16.5. An accumulation of autophagic vacuoles was detected in many tissues including endothelial cells and Schwann cells. Fibroblast cell lines derived from the double-deficient embryos accumulated...

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Pubblicato in:	Mol Biol Cell
Autori principali:	Eskelinen, Eeva-Liisa, Schmidt, Christine Katrin, Neu, Silja, Willenborg, Marion, Fuertes, Graciela, Salvador, Natalia, Tanaka, Yoshitaka, Lüllmann-Rauch, Renate, Hartmann, Dieter, Heeren, Jörg, von Figura, Kurt, Knecht, Erwin, Saftig, Paul
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Cell Biology 2004
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452571/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15121881/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E04-02-0103
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