Disturbed Cholesterol Traffic but Normal Proteolytic Function in LAMP-1/LAMP-2 Double-deficient Fibroblasts

Mice double deficient in LAMP-1 and -2 were generated. The embryos died between embryonic days 14.5 and 16.5. An accumulation of autophagic vacuoles was detected in many tissues including endothelial cells and Schwann cells. Fibroblast cell lines derived from the double-deficient embryos accumulated...

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Auteurs principaux: Eskelinen, Eeva-Liisa, Schmidt, Christine Katrin, Neu, Silja, Willenborg, Marion, Fuertes, Graciela, Salvador, Natalia, Tanaka, Yoshitaka, Lüllmann-Rauch, Renate, Hartmann, Dieter, Heeren, Jörg, von Figura, Kurt, Knecht, Erwin, Saftig, Paul
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2004
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC452571/
https://ncbi.nlm.nih.gov/pubmed/15121881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-02-0103
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