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A molecular characterization of the agonist binding site of a nematode cys-loop GABA receptor

BACKGROUND AND PURPOSE: Cys-loop GABA receptors represent important targets for human chemotherapeutics and insecticides and are potential targets for novel anthelmintics (nematicides). However, compared with insect and mammalian receptors, little is known regarding the pharmacological characteristi...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Kaji, Mark D, Kwaka, Ariel, Callanan, Micah K, Nusrat, Humza, Desaulniers, Jean-Paul, Forrester, Sean G
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523332/
https://ncbi.nlm.nih.gov/pubmed/25850584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13158
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