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Number and Locations of Agonist Binding Sites Required to Activate Homomeric Cys-Loop Receptors

Homo-pentameric Cys-loop receptors contain five identical agonist binding sites, each formed at a subunit interface. To determine the number and locations of binding sites required to generate a stable active state, we constructed a receptor subunit with a mutation that disables the agonist binding...

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Autors principals: Rayes, Diego, De Rosa, María José, Sine, Steven M., Bouzat, Cecilia
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849470/
https://ncbi.nlm.nih.gov/pubmed/19420269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0627-09.2009
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