A mutational and molecular dynamics study of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus: Agonist recognition in the nematode GABA receptor family

The UNC-49 receptor is a unique nematode γ-aminobutyric acid (GABA)-gated chloride channel that may prove to be a novel target for the development of nematocides. Here we have characterized various charged amino acid residues in and near the agonist binding site of the UNC-49 receptor from the paras...

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Detalhes bibliográficos
Publicado no:Int J Parasitol Drugs Drug Resist
Main Authors: Foster, Josh, Cochrane, Everett, Khatami, Mohammad Hassan, Habibi, Sarah A., de Haan, Hendrick, Forrester, Sean G.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Articles from the scientific meeting: "Anthelmintics: From Discovery to Resistance III", pp. 494 - 628.
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287672/
https://ncbi.nlm.nih.gov/pubmed/30361167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2018.10.001
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