Nalaganje...
Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys
Exogenous RNAi triggers such as shRNAs ideally exert their activities exclusively via the antisense strand that binds and silences designated target mRNAs. However, in principle, the sense strand also possesses silencing capacity that may contribute to adverse RNAi side effects including off-target...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4522753/ https://ncbi.nlm.nih.gov/pubmed/26170322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510476112 |
| Oznake: |
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