Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

G protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin binding to GPCRs blocks G protein interaction and redirects signaling to numerous G protein-independent pathways. Here we report the crystal structure of a constitutively active form of human rhodopsin bou...

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Veröffentlicht in:Nature
Hauptverfasser: Kang, Yanyong, Zhou, X. Edward, Gao, Xiang, He, Yuanzheng, Liu, Wei, Ishchenko, Andrii, Barty, Anton, White, Thomas A., Yefanov, Oleksandr, Han, Gye Won, Xu, Qingping, de Waal, Parker W., Ke, Jiyuan, Eileen Tan, M. H., Zhang, Chenghai, Moeller, Arne, West, Graham M., Pascal, Bruce, Van Eps, Ned, Caro, Lydia N., Vishnivetskiy, Sergey A., Lee, Regina J., Suino-Powell, Kelly M., Gu, Xin, Pal, Kuntal, Ma, Jinming, Zhi, Xiaoyong, Boutet, Sébastien, Williams, Garth J., Messerschmidt, Marc, Gati, Cornelius, Zatsepin, Nadia A., Wang, Dingjie, James, Daniel, Basu, Shibom, Roy-Chowdhury, Shatabdi, Conrad, Chelsie, Coe, Jesse, Liu, Haiguang, Lisova, Stella, Kupitz, Christopher, Grotjohann, Ingo, Fromme, Raimund, Jiang, Yi, Tan, Minjia, Yang, Huaiyu, Li, Jun, Wang, Meitian, Zheng, Zhong, Li, Dianfan, Howe, Nicole, Zhao, Yingming, Standfuss, Jörg, Diederichs, Kay, Dong, Yuhui, Potter, Clinton S, Carragher, Bridget, Caffrey, Martin, Jiang, Hualiang, Chapman, Henry N., Spence, John C. H., Fromme, Petra, Weierstall, Uwe, Ernst, Oliver P., Katritch, Vsevolod, Gurevich, Vsevolod V., Griffin, Patrick R., Hubbell, Wayne L., Stevens, Raymond C., Cherezov, Vadim, Melcher, Karsten, Xu, H. Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521999/
https://ncbi.nlm.nih.gov/pubmed/26200343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14656
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