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Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues

Down syndrome (DS), trisomy for chromosome 21, is the most common genetic cause of intellectual disability. The genomic regions on human chromosome 21 (HSA21) are syntenically conserved with regions on mouse chromosomes 10, 16, and 17 (Mmu10, Mmu16, and Mmu17). Recently, we created a genetic model o...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Belichenko, Pavel V., Kleschevnikov, Alexander M., Becker, Ann, Wagner, Grant E., Lysenko, Larisa V., Yu, Y. Eugene, Mobley, William C.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521889/
https://ncbi.nlm.nih.gov/pubmed/26230397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134861
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