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Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway
[Image: see text] The enzyme dihydrofolate reductase (DHFR, E) from Escherichia coli is a paradigm for the role of protein dynamics in enzyme catalysis. Previous studies have shown that the enzyme progresses through the kinetic cycle by modulating the dynamic conformational landscape in the presence...
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| 發表在: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Chemical
Society
2015
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4521799/ https://ncbi.nlm.nih.gov/pubmed/26147643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05707 |
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