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Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion
[Image: see text] The rate-determining step in the catalytic cycle of E. coli dihydrofolate reductase is tetrahydrofolate (THF) product release, which can occur via an allosteric or an intrinsic pathway. The allosteric pathway, which becomes accessible when the reduced cofactor NADPH is bound, invol...
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| Veröffentlicht in: | J Am Chem Soc |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2017
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5562155/ https://ncbi.nlm.nih.gov/pubmed/28737940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05958 |
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