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Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway
[Image: see text] The enzyme dihydrofolate reductase (DHFR, E) from Escherichia coli is a paradigm for the role of protein dynamics in enzyme catalysis. Previous studies have shown that the enzyme progresses through the kinetic cycle by modulating the dynamic conformational landscape in the presence...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Am Chem Soc |
|---|---|
| Prif Awduron: | , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Chemical
Society
2015
|
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4521799/ https://ncbi.nlm.nih.gov/pubmed/26147643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05707 |
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