Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway

[Image: see text] The enzyme dihydrofolate reductase (DHFR, E) from Escherichia coli is a paradigm for the role of protein dynamics in enzyme catalysis. Previous studies have shown that the enzyme progresses through the kinetic cycle by modulating the dynamic conformational landscape in the presence...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Oyen, David, Fenwick, R. Bryn, Stanfield, Robyn L., Dyson, H. Jane, Wright, Peter E.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2015
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521799/
https://ncbi.nlm.nih.gov/pubmed/26147643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05707
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