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A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells.

Replication factor C (RF-C), a complex of five polypeptides, is essential for cell-free SV40 origin-dependent DNA replication and viability in yeast. The cDNA encoding the large subunit of human RF-C (RF-Cp145) was cloned in a Southwestern screen. Using deletion mutants of RF-Cp145 we have mapped th...

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Publicat a:EMBO J
Autors principals: Fotedar, R, Mossi, R, Fitzgerald, P, Rousselle, T, Maga, G, Brickner, H, Messier, H, Kasibhatla, S, Hübscher, U, Fotedar, A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1996
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452166/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8861969/
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