A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells.

Replication factor C (RF-C), a complex of five polypeptides, is essential for cell-free SV40 origin-dependent DNA replication and viability in yeast. The cDNA encoding the large subunit of human RF-C (RF-Cp145) was cloned in a Southwestern screen. Using deletion mutants of RF-Cp145 we have mapped th...

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Autori principali: Fotedar, R, Mossi, R, Fitzgerald, P, Rousselle, T, Maga, G, Brickner, H, Messier, H, Kasibhatla, S, Hübscher, U, Fotedar, A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC452166/
https://ncbi.nlm.nih.gov/pubmed/8861969
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