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Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA

Summary: Increased DNA replication and metastasis are hallmarks of cancer progression, while deregulated proliferation often triggers sustained replication stresses in cancer cells. How cancer cells overcome the growth stress and proceed to metastasis remains largely elusive. Proliferating cell nucl...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Yuan-Liang Wang, Chuan-Chun Lee, Yi-Chun Shen, Pei-Le Lin, Wan-Rong Wu, You-Zhe Lin, Wei-Chung Cheng, Han Chang, Yu Hung, Yi-Chun Cho, Liang-Chih Liu, Wei-Ya Xia, Jin-Huei Ji, Ji-An Liang, Shu-Fen Chiang, Chang-Gong Liu, Jun Yao, Mien-Chie Hung, Shao-Chun Wang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021-08-01
Schriftenreihe:Cell Reports
Schlagworte:
PCNA
pY211 PCNA
ssDNA
cGAS
innate immune response
type I interferon
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2211124721009712
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