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Engineering synthetic antibody inhibitors specific for LD2 or LD4 motifs of paxillin
Focal adhesion protein paxillin links integrin and growth factor signaling to actin cytoskeleton. Most of paxillin signaling activity is regulated via leucine-rich LD motifs (LD1-LD5) located at the N-terminus. Here, we demonstrate a method to engineer highly selective synthetic antibodies (sABs) ag...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4521624/ https://ncbi.nlm.nih.gov/pubmed/26087144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.06.004 |
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