AMP-activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma

The Hedgehog (Hh) pathway regulates cell differentiation and proliferation during development by controlling the Gli transcription factors. Cell fate decisions and progression toward organ and tissue maturity must be coordinated and how energy sensor regulates Hh pathway is not clear. AMP-activated...

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Udgivet i:Cell Rep
Main Authors: Li, Yen-Hsing, Luo, Jia, Mosley, Yung-Yi C., Hedrick, Victoria E., Paul, Lake N., Chang, Julia, Zhang, GuangJun, Wang, Yu-Kuo, Banko, Max R., Brunet, Anne, Kuang, Shihuan, Wu, Jen-Leih, Chang, Chun-Ju, Scott, Matthew P., Yang, Jer-Yen
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521589/
https://ncbi.nlm.nih.gov/pubmed/26190112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.054
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