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Dexamethasone destabilizes Nmyc to inhibit the growth of Hedgehog-associated medulloblastoma
Mouse studies indicate that the synthetic glucocorticoid Dexamethasone (Dex) impairs the proliferation of granule neuron precursors in the cerebellum, which are transformed to medulloblastoma by activation of Sonic hedgehog (Shh) signaling. Here we show that Dex treatment also inhibits Shh-induced t...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896447/ https://ncbi.nlm.nih.gov/pubmed/20530674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0554 |
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