Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma

Origins of the brain tumor, medulloblastoma, from stem cells or restricted progenitor cells are unclear. To investigate this, we activated oncogenic Hedgehog (Hh) signaling in multipotent and lineage-restricted CNS progenitors. We observed that normal unipotent cerebellar granule neuron precursors (...

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Hlavní autoři: Schüller, Ulrich, Heine, Vivi M., Mao, Junhao, Kho, Alvin T., Dillon, Allison K., Han, Young-Goo, Huillard, Emmanuelle, Sun, Tao, Ligon, Azra H., Qian, Ying, Ma, Qiufu, Alvarez-Buylla, Arturo, McMahon, Andrew P., Rowitch, David H., Ligon, Keith L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597270/
https://ncbi.nlm.nih.gov/pubmed/18691547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.07.005
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