Sonic Hedgehog-Induced Histone Deacetylase Activation Is Required for Cerebellar Granule Precursor Hyperplasia in Medulloblastoma

Medulloblastoma, the most common pediatric brain tumor, is thought to arise from deregulated proliferation of cerebellar granule precursor (CGP) cells. Sonic hedgehog (Shh) is the primary mitogen that regulates proliferation of CGP cells during the early stages of postnatal cerebellum development. A...

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Detalhes bibliográficos
Principais autores: Lee, Seung Joon, Lindsey, Stephan, Graves, Bruce, Yoo, Soonmoon, Olson, James M., Langhans, Sigrid A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739791/
https://ncbi.nlm.nih.gov/pubmed/23951168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071455
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