Sonic Hedgehog-Induced Histone Deacetylase Activation Is Required for Cerebellar Granule Precursor Hyperplasia in Medulloblastoma

Medulloblastoma, the most common pediatric brain tumor, is thought to arise from deregulated proliferation of cerebellar granule precursor (CGP) cells. Sonic hedgehog (Shh) is the primary mitogen that regulates proliferation of CGP cells during the early stages of postnatal cerebellum development. A...

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Bibliografiska uppgifter
Huvudupphovsmän: Lee, Seung Joon, Lindsey, Stephan, Graves, Bruce, Yoo, Soonmoon, Olson, James M., Langhans, Sigrid A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739791/
https://ncbi.nlm.nih.gov/pubmed/23951168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071455
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