Sonic Hedgehog-Induced Histone Deacetylase Activation Is Required for Cerebellar Granule Precursor Hyperplasia in Medulloblastoma

Medulloblastoma, the most common pediatric brain tumor, is thought to arise from deregulated proliferation of cerebellar granule precursor (CGP) cells. Sonic hedgehog (Shh) is the primary mitogen that regulates proliferation of CGP cells during the early stages of postnatal cerebellum development. A...

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Hlavní autoři: Lee, Seung Joon, Lindsey, Stephan, Graves, Bruce, Yoo, Soonmoon, Olson, James M., Langhans, Sigrid A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739791/
https://ncbi.nlm.nih.gov/pubmed/23951168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071455
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