Plerixafor+G-CSF–mobilized CD34(+) cells represent an optimal graft source for thalassemia gene therapy

Globin gene therapy requires abundant numbers of highly engraftable, autologous hematopoietic stem cells expressing curative levels of β-globin on differentiation. In this study, CD34(+) cells from 31 thalassemic patients mobilized with hydroxyurea+granulocyte colony-stimulating factor (G-CSF), G-CS...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Karponi, Garyfalia, Psatha, Nikoletta, Lederer, Carsten Werner, Adair, Jennifer Eileen, Zervou, Fani, Zogas, Nikolaos, Kleanthous, Marina, Tsatalas, Constantinos, Anagnostopoulos, Achilles, Sadelain, Michel, Rivière, Isabelle, Stamatoyannopoulos, George, Yannaki, Evangelia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520876/
https://ncbi.nlm.nih.gov/pubmed/26089395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-629618
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