The Functional Effect of Repeated Cryopreservation on Transduced CD34(+) Cells from Patients with Thalassemia

Stable gene marking and effective engraftment of gene-modified CD34(+) hematopoietic stem cells is a prerequisite for gene therapy success but may be challenged by the inevitable cryopreservation of the final product prior to extensive quality assurance testing. We investigated the β-globin gene tra...

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Bibliografiska uppgifter
I publikationen:Hum Gene Ther Methods
Huvudupphovsmän: Karponi, Garyfalia, Papayanni, Penelope-Georgia, Zervou, Fani, Bouinta, Asimina, Anagnostopoulos, Achilles, Yannaki, Evangelia
Materialtyp: Artigo
Språk:Inglês
Publicerad: Mary Ann Liebert, Inc., publishers 2018
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206548/
https://ncbi.nlm.nih.gov/pubmed/30079761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2018.032
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