Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer

Anti-HER2 murine monoclonal antibody 1E11 has strong and synergistic anti-tumor activity in HER2-overexpressing gastric cancer cells when used in combination with trastuzumab. We presently optimized this antibody for human therapeutics. First, the complementarity determining regions (CDRs) of the mu...

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發表在:PLoS One
Main Authors: Ko, Bong-Kook, Choi, Soyoung, Cui, Lei Guang, Lee, Young-Ha, Hwang, In-Sik, Kim, Kyu-Tae, Shim, Hyunbo, Lee, Jong-Seo
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520604/
https://ncbi.nlm.nih.gov/pubmed/26225765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134600
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