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In Vitro Antibody Affinity Maturation Targeting Germline Hotspots
Affinity-matured antibodies can exhibit increased biological efficacy. Regardless of whether an antibody is isolated from a hybridoma or a human Fv phage library, the antibody affinity for its target may need improvement for therapeutic applications. An increased affinity may allow for a reduced dos...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3473074/ https://ncbi.nlm.nih.gov/pubmed/19252855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-59745-554-1_15 |
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