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Affinity Maturation of an Epidermal Growth Factor Receptor Targeting Human Monoclonal Antibody ER414 by CDR Mutation

It is well established that blocking the interaction of EGFR with growth factors leads to the arrest of tumor growth, resulting in tumor cell death. ER414 is a human monoclonal antibody (mAb) derived by guided selection of the mouse mAb A13. The ER414 exhibited a ~17-fold lower affinity and, as a re...

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Hlavní autoři: Chang, Ki-Hwan, Kim, Min-Soo, Hong, Gwang-Won, Seo, Mi-Sun, Shin, Yong-Nam, Kim, Se-Ho
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Association of Immunologists 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467414/
https://ncbi.nlm.nih.gov/pubmed/23091439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4110/in.2012.12.4.155
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