Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification

Antibodies can rapidly evolve in specific response to antigens. Affinity maturation drives this evolution through cycles of mutation and selection leading to enhanced antibody specificity and affinity. Elucidating the biophysical mechanisms that underlie affinity maturation is fundamental to underst...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Jeliazkov, Jeliazko R., Sljoka, Adnan, Kuroda, Daisuke, Tsuchimura, Nobuyuki, Katoh, Naoki, Tsumoto, Kouhei, Gray, Jeffrey J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840193/
https://ncbi.nlm.nih.gov/pubmed/29545810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00413
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados