Učitavanje...
T cell receptor CDR2β and CDR3β loops collaborate functionally to shape the iNKT cell repertoire
Mouse iNKT cell receptors (iNKT TCRs) use a single Vα14-Jα18 sequence and Vβs that are almost always Vβ8.2, Vβ7 or Vβ2, although the basis of this differential usage is unclear. We show that the Vβ bias occurs as a consequence of the CDR2β loops determining the affinity of the iNKT TCR for CD1d/glyc...
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| Glavni autori: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2965025/ https://ncbi.nlm.nih.gov/pubmed/19592274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.05.010 |
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