T cell receptor CDR2β and CDR3β loops collaborate functionally to shape the iNKT cell repertoire

Mouse iNKT cell receptors (iNKT TCRs) use a single Vα14-Jα18 sequence and Vβs that are almost always Vβ8.2, Vβ7 or Vβ2, although the basis of this differential usage is unclear. We show that the Vβ bias occurs as a consequence of the CDR2β loops determining the affinity of the iNKT TCR for CD1d/glyc...

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Main Authors: Mallevaey, Thierry, Scott-Browne, James P., Matsuda, Jennifer L., Young, Mary H., Pellicci, Daniel G., Patel, Onisha, Thakur, Meena, Kjer-Nielsen, Lars, Richardson, Stewart K., Cerundolo, Vincenzo, Howell, Amy R., McCluskey, James, Godfrey, Dale I., Rossjohn, Jamie, Marrack, Philippa, Gapin, Laurent
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965025/
https://ncbi.nlm.nih.gov/pubmed/19592274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.05.010
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